Paracetamol, also known as acetaminophen or APAP, is a medicine used to treat pain and fever. It is typically used for mild to moderate pain relief. Evidence for its use to relieve fever in children is mixed. It is often sold in combination with other medications, such as in many cold medications. In combination with opioid pain medication, paracetamol is also used for severe pain such as cancer pain and pain after surgery. It is typically used either by mouth or rectally but is also available intravenously. Effects last between two and four hour
In the world the production of paracetamol is highly concentrated in China and India, the two countries occupy about 83.86% of the global production (China 59.02% and India 24.84%) in 2016, and their market share has been increasing in recent years.
In 2016, United States is still the biggest market in the world, it has a consumption of nearly 49 kilos MT, followed by China (34.6 kilo MT) and Europe (48.4 kilo MT). Although India has large production, its consumption is not too much. Although sales of paracetamol brought a lot of opportunities, the study group recommends the new entrants who just having money but without technical advantage and downstream support, do not to enter into the paracetamol field hastily.
Paracetamol is generally safe at recommended doses. Serious skin rashes may rarely occur, and too high a dose can result in liver failure. It appears to be safe during pregnancy and when breastfeeding. In those with liver disease, it may still be used, but in lower doses. Paracetamol is classified as a mild analgesic. It does not have significant anti-inflammatory activity and how it works is not entirely clear.